How does a Fecal Immunochemical Test (FIT) differ from a Guaiac-based test(s)? What are the advantages?
Conventional Guaiac-based tests that are used for the detection of fecal occult blood do not provide a high degree of accuracy. Guaiac-based tests are highly affected by a patient's diet, due to the fact that the assay is testing for the presence of peroxidase activity. However, apart from human hemoglobin, other substances have similar peroxidase activity, such as meat, certain vegetables, fruit and certain drugs (i.e. vitamin C). Patients must abstain from consuming any of these items for three days prior to taking the Guaiac test. Also, three samples from three separate bowel movements must be obtained.
OC FIT-CHEK® tests are immunological based, specifically designed to test for the presence of human hemoglobin in feces. This will increase sensitivity and specificity while decreasing false positives and false negatives. There is no need for patients to adhere to any dietary restrictions. The sampling procedure is user friendly, requiring virtually no fecal handling and only one sample versus the three required for Guaiac-based tests. Patient compliance will increase based on the added convenience.